In order to adjust procedures in Serbia to the ones of other European countries, a strategic planning of cluster development in Serbia needs to be performed. There are more than 55 clusters in Serbia. Clusters represent significant tool of sustainable economic development. LEDIB Cluster House, an innovative organization, was formed in Nis in purpose of developing clusters all over South-East Serbia, with the mission to establish cooperation of business community organized into clusters and public and scientific-research sectors. Increase in the number of clusters in Serbia indicates that there is a need to create specific training for associates in the area of cluster development in Serbia. By applying the multidisciplinary approach in training of cluster facilitators, based on cooperation of Universities, business organizations and clusters, and with strong support of public sector, LEDIB Cluster House is contributing to creation of expert assistants – cluster facilitators, who will enable professional development of clusters in Serbia, strengthening thus the SME sector competitiveness through support to innovations.